![]() ![]() Received: MaAccepted: OctoPublished: October 21, 2016Ĭopyright: © 2016 Boere et al. PLoS ONE 11(10):Įditor: Klaus Ebmeier, University of Oxford, UNITED KINGDOM However, if these findings can be reproduced in a more comprehensive study group, then the possible induction of anterograde amnesia is not a justifiable reason for clinicians to disregard ECT as a treatment option.Ĭitation: Boere E, Kamperman AM, van 't Hoog AE, van den Broek WW, Birkenhäger TK (2016) Anterograde Amnesia during Electroconvulsive Therapy: A Prospective Pilot-Study in Patients with Major Depressive Disorder. The main limitations of our study are its naturalistic design, possibly compromising internal validity, and its small sample size. Age was identified as a very important covariate. Four weeks after treatment discontinuation, these memory functions had recovered. Findings on immediate recall were less consistent. ![]() In patients with major depressive disorder, ECT had a significant effect on delayed memory function (p<0.01 with large effect sizes). Correlations with hypothesized covariates were calculated. Differences were tested using repeated measures ANOVA and paired t-tests. Primary outcome measure was immediate recall secondary outcome measures were delayed recall, recognition, and visual association. Controls treated with antidepressants (n = 9) were matched for age, gender and depression severity. Recruitment took place between March 2010-March 2011 and March 2012-March 2013. Subjects met DSM-IV criteria for major depressive disorder. In a prospective naturalistic study, anterograde memory function was assessed among inpatients who underwent ECT (n = 11). The present study aims to evaluate the severity and course of anterograde amnesia in severely depressed patients undergoing ECT. However, neurocognitive side-effects such as anterograde amnesia still regularly occur. Electroconvulsive therapy (ECT) is considered an effective treatment for major depression with melancholic features. ![]()
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